Frequently Asked Questions

STEGLUJAN contains 2 prescription medicines called ertugliflozin (STEGLATRO^®) and sitagliptin (JANUVIA^®). STEGLUJAN is used in adults with type 2 diabetes to improve blood sugar (glucose) along with diet and exercise.

• STEGLUJAN is not for people with type 1 diabetes. It may increase the risk of diabetic ketoacidosis in these people.
• If you have had pancreatitis (inflammation of the pancreas) in the past, it is not known if you have a higher chance of getting pancreatitis while you take STEGLUJAN.
• It is not known if STEGLUJAN is safe and effective in children under 18 years of age.

STEGLUJAN works with the pancreas to increase insulin production, the liver to reduce sugar production, and the kidneys to remove some sugar when you pee.

STEGLUJAN is a once-daily pill you take in the morning, with or without food. Not an injection. You can make STEGLUJAN part of your morning routine.

Although it's not for weight loss, STEGLUJAN may help you lose some weight.^c

^cSTEGLUJAN was studied for 26 weeks in adults with type 2 diabetes. At the starting dose, people lost an average of 5.95 pounds from 200.18 pounds. At the highest dose, people lost an average of 6.17 pounds from 201.06 pounds. Those on placebo lost an average of 1.1 pounds from 209.44 pounds.

STEGLUJAN has been shown to lower systolic blood pressure, but it is not a drug for lowering blood pressure.^d

^dSTEGLUJAN was studied for 26 weeks in adults with type 2 diabetes. At the starting dose, people’s systolic blood pressure decreased, on average, 2.4 mmHg from a 130.7 mmHg baseline. At the highest dose, people’s systolic blood pressure decreased, on average, 3.5 mmHg from a 129.2 mmHg baseline. Those on placebo showed an increase in systolic blood pressure, on average, of 1.6 mmHg from a 127.4 mmHg baseline.

Active ingredients: ertugliflozin and sitagliptin. Inactive ingredients: microcrystalline cellulose, dibasic calcium phosphate anhydrous, croscarmellose sodium, sodium stearyl fumarate, and magnesium stearate. The tablet film coating contains the following inactive ingredients: hypromellose, hydroxypropyl cellulose, titanium dioxide, iron oxide red, iron oxide yellow, ferrosoferric oxide/black iron oxide, and carnauba wax.

STEGLUJAN may cause serious side effects, including:

• Inflammation of the pancreas (pancreatitis) which may be severe and lead to death. Certain medical problems make you more likely to get pancreatitis.

Before you start taking STEGLUJAN, tell your doctor if you have ever had:

• pancreatitis
• a history of alcoholism
• kidney problems
• stones in your gallbladder (gallstones)
• high blood triglyceride levels

Stop taking STEGLUJAN and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis.

• Ketoacidosis (increased ketones in your blood or urine). Ketoacidosis has happened in people who have type 1 diabetes or type 2 diabetes during treatment with STEGLUJAN. Ketoacidosis has also happened in people with diabetes who were sick or who had surgery during treatment with STEGLUJAN. Ketoacidosis is a serious condition, which may need to be treated in a hospital. Ketoacidosis may lead to death. Ketoacidosis can happen even if your blood sugar is less than 250 mg/dL. Stop taking STEGLUJAN and call your doctor right away if you get any of the following symptoms:
  • nausea
  • vomiting
  • stomach-area (abdominal) pain
  • tiredness
  • trouble breathing

If you get any of these symptoms during treatment with STEGLUJAN, if possible check for ketones in your urine, even if your blood sugar is less than 250 mg/dL.

• Amputations. STEGLUJAN may increase your risk of lower limb amputations. You may be at a higher risk of lower limb amputation if you:
  • have a history of amputation
  • have had blocked or narrowed blood vessels, usually in your leg
  • have damage to the nerves (neuropathy) in your leg
  • have had diabetic foot ulcers or sores

Call your doctor right away if you have new pain or tenderness, any sores, ulcers, or infections in your leg or foot. Your doctor may decide to stop your STEGLUJAN for a while if you have any of these signs or symptoms. Talk to your doctor about proper foot care.

• Dehydration. STEGLUJAN can cause some people to become dehydrated (the loss of body water and salt). Dehydration may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). There have been reports of sudden worsening of kidney function in people who are taking STEGLUJAN. You may be at risk of dehydration if you:
  • have low blood pressure
  • take medicines to lower your blood pressure, including water pills (diuretics)
  • have kidney problems
  • are on a low sodium (salt) diet
  • are 65 years of age or older

Talk to your doctor about what you can do to prevent dehydration including how much fluid you should drink on a daily basis.

• Vaginal yeast infection. Women who take STEGLUJAN may get vaginal yeast infections. Symptoms of a vaginal yeast infection include:
  • vaginal odor
  • white or yellowish vaginal discharge (discharge may be lumpy or look like cottage cheese)
  • vaginal itching

• Yeast infection of the penis (balanitis or balanoposthitis). Men who take STEGLUJAN may get a yeast infection of the skin around the penis. Certain men who are not circumcised may have swelling of the penis that makes it difficult to pull back the skin around the tip of your penis. Other symptoms of yeast infection of the penis include:
  • redness, itching, or swelling of the penis
  • rash of the penis
  • foul smelling discharge from the penis
  • pain in the skin around your penis

Talk to your doctor about what to do if you get symptoms of a yeast infection of the vagina or penis. Your doctor may suggest you use an over-the-counter antifungal medicine. Talk to your doctor right away if you use an over-the-counter antifungal medicine and your symptoms do not go away.

• Heart failure. Heart failure means your heart does not pump blood well enough. Before you start taking STEGLUJAN, tell your doctor if you have ever had heart failure or have problems with your kidneys. Contact your doctor right away if you have any of the following symptoms:
  • increasing shortness of breath or trouble breathing, especially when you lie down
  • swelling or fluid retention, especially in the feet, ankles or legs
  • an unusually fast increase in weight
  • unusual tiredness

These may be symptoms of heart failure.

STEGLUJAN may have other side effects. See Possible Risks & Side Effects to learn more.

Yes, if you have been prescribed STEGLUJAN, you may pay as little as $0 per prescription.*

Eligible, privately insured patients may pay as little as $0 per prescription on each of up to 12 qualifying prescriptions. Maximum savings is $583 per prescription.

See Coupon Offer

*Not all patients are eligible. Certain restrictions apply. Please see Terms and Conditions.

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take 2 doses of STEGLUJAN at the same time.

Even if you’re working hard to eat right and exercise, your A1C levels may increase over time. This is not unusual and can happen no matter how hard you work. You're not alone. Many people with type 2 diabetes often need to add or change medications to help get A1C levels under control. STEGLUJAN builds on the work you’re already doing. It can help you make progress lowering your A1C.